Large Volume Parenteral Infusion Bottles

Large volume parenterals (LVPs) are the liter-scale fluids given by intravenous infusion — saline, dextrose, nutrition and irrigation solutions. Much IV fluid now ships in plastic bags, but glass infusion bottles remain important for drugs and formulations that adsorb onto, leach plasticiser from, or react with plastic, where an inert glass surface is essential.

Made from Type I or Type II glass and sealed with an infusion stopper, these bottles withstand terminal autoclave sterilization and present a clear, particle-visible container for a product delivered directly into the vein.

Intravenous saline and dextrose, parenteral nutrition, irrigation solutions, IV drug diluents and plasma volume expanders, in hospitals and infusion centres, and for drugs incompatible with plastic IV containers, plus veterinary infusion.

A large glass bottle in Type I borosilicate (sensitive drugs) or Type II treated soda-lime, with a 32 mm infusion finish for a rubber infusion stopper and aluminum crimp seal, and a hanger or band for the IV pole. Clear glass lets the fluid be inspected for particles and clarity before use; amber is used where needed.

LVPs are usually terminally sterilized in the autoclave, so the glass, stopper and seal are validated to survive the cycle and maintain integrity. Container-closure integrity, particulate control and clarity are critical for an injectable given in volume. Choose Type I for sensitive drugs; Type II suits many standard solutions.

Large infusion bottles are molded (blow-and-blow) from pharmaceutical glass with a 32 mm infusion finish, then annealed to withstand autoclaving. Produced and inspected to pharmaceutical standards for glass type, dimensions, defects and clarity; the closure system is validated with the bottle.